Toxic pneumopathy by Trema micrantha in sheep in the State of Santa Catarina, Brazil

ABSTRACT: Poisoning by Trema micrantha commonly causes hepatocellular necrosis in cattle, sheep, and goats edema cerebral hemorrhage horses. This plant can cause toxic pneumopathy there is only one report of the natural form experimental State Rio Grande do Sul. study aimed to an outbreak respiratory poisoning T. sheep. Six sheep developed clinical signs after consumption four them died two recovered treatment with dexamethasone. The presented tachypnea, noisy breathing, face, eyelids, vulva, subcutaneous emphysema on face neck. Necropsy (Sheep 2, 3, 4) showed uncollapsed, heavy, diffuse red lungs evident costal impressions a moderate amount serosanguineous fluid flowed at section. liver had lobular pattern. histopathology three necropsied congestion formation hyaline membranes within accentuated alveoli, addition thickening alveolar septa due mild type II pneumocyte hyperplasia also infiltrate macrophages, lymphocytes, plasma cells, neutrophils lumen bronchi, bronchioles. Sheep 3 pneumocytes enlarged hyperchromatic nuclei, sometimes binucleated nucleoli, and, some regions, were desquamated forming small syncytia multifocal bronchial epithelium. anti-cytokeratin IHC evaluation marked intracytoplasmic staining hyperplastic bronchiolar epithelium evaluated centrilobular necrosis. It seems be second spontaneous developing lung lesions described Brazil first Santa Catarina.